| Airport | Main terminal | Gates of its own | Departures | Nonstop destinations |
|---|
| American at Dallas/Fort Worth (DFW) | Terminal B, Concourse B | 137 | 872/day | 237 |
| American at Charlotte (CLT) | Concourse E | 108 | 655/day | 169 |
| American at Philadelphia (PHL) | Terminal F, Concourse F | 86 | 327/day | 106 |
| American at O’Hare (ORD) | Terminal 3, Concourse L | 72 | 502/day | 162 |
| American at Miami (MIA) | Concourse D | 70 | 316/day | 143 |
| American at Phoenix (PHX) | Terminal 4, Concourse B | 54 | 237/day | 96 |
| American at Washington National (DCA) | Terminal 2, Concourse E | 36 | 244/day | 88 |
| American at Los Angeles (LAX) | Terminal 4 | 22 | 139/day | 58 |
| American at New York LaGuardia (LGA) | Terminal B | 17 | 137/day | 48 |
| American at Boston (BOS) | Terminal B, Concourse B | 16 | 94/day | 30 |
| American at New York JFK | Terminal 8 | 14 | 85/day | 44 |
| American at Pittsburgh (PIT) | Concourse B | 13 | 35/day | 11 |
| American at Tampa (TPA) | Concourse F | 12 | 39/day | 10 |
| American at Orlando (MCO) | Terminal B | 12 | 37/day | 10 |
| American at San Antonio (SAT) | Terminal B, Concourse B | 10 | 28/day | 10 |
| American at London Heathrow (LHR) | Terminal 3 | 10 | 21/day | 10 |
| American at Raleigh/Durham (RDU) | Terminal 2, Concourse C | 9 | 51/day | 13 |
| American at Las Vegas (LAS) | Terminal 1, Concourse D | 9 | 44/day | 9 |
| American at Indianapolis (IND) | Concourse B | 9 | 42/day | 11 |
| American at Columbus (CMH) | Concourse B | 9 | 40/day | 11 |
| American at Cleveland (CLE) | Concourse C | 9 | 31/day | 10 |
| American at Detroit (DTW) | Terminal E, Concourse D | 9 | 20/day | 8 |
| American at Nashville (BNA) | Concourse C | 8 | 49/day | 13 |
| American at Cincinnati (CVG) | Concourse B | 8 | 33/day | 10 |
| American at St. Louis (STL) | Terminal 1, Concourse C | 8 | 30/day | 10 |
| American at Kansas City (MCI) | Concourse A | 8 | 27/day | 7 |
| American at Greensboro (GSO) | not listed | 8 | 23/day | 8 |
| American at Birmingham (BHM) | Concourse B | 8 | 21/day | 6 |
| American at San Francisco (SFO) | Terminal 1, Concourse B | 7 | 47/day | 8 |
| American at Houston Bush (IAH) | Terminal A, Concourse A | 7 | 35/day | 15 |
| American at Memphis (MEM) | not listed | 7 | 25/day | 8 |
| American at Louisville (SDF) | Concourse B | 7 | 25/day | 7 |
| American at Madison (MSN) | not listed | 7 | 20/day | 8 |
| American at Northwest Arkansas (XNA) | Concourse A | 6 | 28/day | 9 |
| American at Seattle (SEA) | Concourse D | 6 | 26/day | 10 |
| American at Norfolk (ORF) | Concourse A | 6 | 26/day | 8 |
| American at Richmond (RIC) | Concourse A | 6 | 25/day | 6 |
| American at New Orleans (MSY) | Concourse B | 6 | 23/day | 8 |
| American at Minneapolis/St. Paul (MSP) | Terminal 1, Concourse E | 6 | 23/day | 8 |
| American at Buffalo (BUF) | not listed | 6 | 22/day | 7 |
| American at Harrisburg (MDT) | Concourse C | 6 | 18/day | 5 |
| American at Grand Rapids (GRR) | Concourse A | 6 | 16/day | 6 |
| American at Atlanta (ATL) | Terminal N, Concourse T | 5 | 43/day | 11 |
| American at Austin (AUS) | not listed | 5 | 38/day | 9 |
| American at Denver (DEN) | Concourse C | 5 | 33/day | 10 |
| American at Greenville/Spartanburg (GSP) | Concourse A | 5 | 26/day | 7 |
| American at San Diego (SAN) | Terminal 2 | 5 | 26/day | 8 |
| American at Wilmington (ILM) | not listed | 5 | 24/day | 8 |
| American at Hartford (BDL) | not listed | 5 | 21/day | 6 |
| American at Columbia (CAE) | not listed | 5 | 19/day | 6 |
| American at Rochester (ROC) | Concourse A | 5 | 16/day | 5 |
| American at Dayton (DAY) | Concourse A | 5 | 15/day | 5 |
| American at Baltimore/Washington (BWI) | Concourse C | 5 | 15/day | 6 |
| American at Syracuse (SYR) | not listed | 5 | 15/day | 6 |
| American at Charleston (CHS) | Concourse B | 4 | 26/day | 7 |
| American at Jacksonville (JAX) | Concourse C | 4 | 26/day | 7 |
| American at Oklahoma City (OKC) | not listed | 4 | 23/day | 8 |
| American at Fort Lauderdale (FLL) | Terminal 3, Concourse E | 4 | 21/day | 7 |
| American at Tulsa (TUL) | Concourse A | 4 | 19/day | 9 |
| American at Tucson (TUS) | Concourse B | 4 | 19/day | 4 |
| American at Des Moines (DSM) | not listed | 4 | 18/day | 8 |
| American at Salt Lake City (SLC) | Concourse B | 4 | 17/day | 8 |
| American at Omaha (OMA) | Concourse A | 4 | 17/day | 6 |
| American at Providence (PVD) | not listed | 4 | 17/day | 4 |
| American at Huntsville (HSV) | not listed | 4 | 16/day | 4 |
| American at West Palm Beach (DJT) | Concourse B | 4 | 16/day | 7 |
| American at El Paso (ELP) | Concourse A | 4 | 15/day | 4 |
| American at Fort Myers (RSW) | Concourse D | 4 | 14/day | 6 |
| American at Manchester (MHT) | not listed | 4 | 13/day | 4 |
| American at Cedar Rapids (CID) | not listed | 4 | 13/day | 7 |
| American at Burlington (BTV) | not listed | 4 | 12/day | 5 |
| American at Tallahassee (TLH) | Concourse A | 4 | 12/day | 4 |
| American at Lubbock (LBB) | not listed | 4 | 10/day | 2 |
| American at Destin/Fort Walton Beach (VPS) | Concourse A | 4 | 10/day | 4 |
| American at Ontario (ONT) | Terminal 4 | 4 | 9/day | 3 |
| American at Tri-Cities (TRI) | not listed | 4 | 8-9/day | 3 |
| American at Baton Rouge (BTR) | Concourse B | 4 | 7-8/day | 2 |
| American at Knoxville (TYS) | not listed | 3 | 26/day | 7 |
| American at Newark (EWR) | Terminal A, Concourse A | 3 | 21/day | 6 |
| American at Savannah (SAV) | not listed | 3 | 20/day | 7 |
| American at Orange County (SNA) | not listed | 3 | 19/day | 5 |
| American at Springfield (SGF) | not listed | 3 | 17/day | 3 |
| American at Albuquerque (ABQ) | Concourse B | 3 | 16/day | 6 |
| American at Little Rock (LIT) | not listed | 3 | 16/day | 7 |
| American at Albany (ALB) | Concourse B | 3 | 16/day | 4 |
| American at Pensacola (PNS) | not listed | 3 | 16/day | 5 |
| American at Lexington (LEX) | Concourse B | 3 | 15/day | 5 |
| American at Portland (PDX) | Concourse C | 3 | 14/day | 6 |
| American at Roanoke (ROA) | not listed | 3 | 13/day | 6 |
| American at Sacramento (SMF) | Terminal A, Concourse A | 3 | 13/day | 5 |
| American at Myrtle Beach (MYR) | Concourse A | 3 | 13/day | 4 |
| American at Wichita (ICT) | not listed | 3 | 11/day | 4 |
| American at Fort Wayne (FWA) | not listed | 3 | 10/day | 3 |
| American at Washington Dulles (IAD) | Concourse B | 3 | 9/day | 4 |
| American at San Juan (SJU) | Terminal C, Concourse C | 3 | 8-9/day | 5 |
| American at Reno (RNO) | Concourse C | 3 | 8/day | 2 |
| American at Charlottesville (CHO) | not listed | 3 | 7-8/day | 2 |
| American at Moline/Quad Cities (MLI) | Concourse A | 3 | 7-8/day | 3 |
| American at Gainesville (GNV) | not listed | 3 | 7/day | 4 |
| American at McAllen (MFE) | not listed | 3 | 7/day | 2 |
| American at Peoria (PIA) | not listed | 3 | 6-7/day | 3 |
| American at Traverse City (TVC) | not listed | 3 | 6-7/day | 4 |
| American at Mobile (MOB) | not listed | 3 | 5/day | 2 |
| American at Dublin (DUB) | Terminal 2 | 3 | 3/day | 4 |
| American at Toronto Pearson (YYZ) | Terminal 3, Concourse A | 2 | 26/day | 7 |
| American at Chattanooga (CHA) | not listed | 2 | 14/day | 4 |
| American at Bangor (BGR) | not listed | 2 | 12/day | 5 |
| American at Midland (MAF) | not listed | 2 | 11/day | 3 |
| American at Jackson (JAN) | not listed | 2 | 9-10/day | 3 |
| American at South Bend (SBN) | not listed | 2 | 7-8/day | 3 |
| American at Panama City Beach (ECP) | not listed | 2 | 7-8/day | 3 |
| American at Akron/Canton (CAK) | not listed | 2 | 7-8/day | 3 |
| American at Boise (BOI) | Concourse B | 2 | 7/day | 3 |
| American at Evansville (EVV) | Concourse B | 2 | 6-7/day | 4 |
| American at Augusta (AGS) | not listed | 2 | 6-7/day | 2 |
| American at Sarasota (SRQ) | Concourse B | 2 | 6-7/day | 5 |
| American at Colorado Springs (COS) | not listed | 2 | 6-7/day | 3 |
| American at Palm Springs (PSP) | not listed | 2 | 6-7/day | 3 |
| American at San Jose (SJC) | Terminal A | 2 | 6/day | 2 |
| American at Gulfport/Biloxi (GPT) | not listed | 2 | 5-6/day | 2 |
| American at Honolulu (HNL) | Terminal 2, Concourse C | 2 | 5-6/day | 4 |
| American at Wilkes-Barre/Scranton (AVP) | not listed | 2 | 5-6/day | 2 |
| American at Grand Junction (GJT) | not listed | 2 | 5-6/day | 2 |
| American at Montgomery (MGM) | not listed | 2 | 5-6/day | 2 |
| American at Killeen (GRK) | not listed | 2 | 5/day | 1 |
| American at Fayetteville (FAY) | not listed | 2 | 5/day | 1 |
| American at Appleton (ATW) | not listed | 2 | 5/day | 3 |
| American at Spokane (GEG) | Concourse C | 2 | 5/day | 3 |
| American at Rapid City (RAP) | not listed | 2 | 4-5/day | 4 |
| American at Bakersfield (BFL) | not listed | 2 | 4-5/day | 2 |
| American at Bloomington (BMI) | not listed | 2 | 4/day | 2 |
| American at Monterey (MRY) | not listed | 2 | 4/day | 2 |
| American at St. George (SGU) | not listed | 2 | 4/day | 2 |
| American at Charleston (CRW) | Concourse C | 2 | 4/day | 2 |
| American at Jackson Hole (JAC) | not listed | 2 | 3-4/day | 6 |
| American at Lincoln (LNK) | not listed | 2 | 3/day | 2 |
| American at Santa Rosa (STS) | not listed | 2 | 3/day | 2 |
| American at Rochester (RST) | not listed | 2 | 3/day | 1 |
| American at Aspen (ASE) | not listed | 2 | 2-3/day | 3 |
| American at Frankfurt (FRA) | Terminal 3, Concourse J | 2 | 2/day | 3 |
| American at Asheville (AVL) | not listed | 1 | 17/day | 7 |
| American at Sioux Falls (FSD) | not listed | 1 | 8-9/day | 3 |
| American at Fresno (FAT) | not listed | 1 | 8-9/day | 2 |
| American at Santa Fe (SAF) | not listed | 1 | 8-9/day | 4 |
| American at Corpus Christi (CRP) | not listed | 1 | 7/day | 1 |
| American at Columbia (COU) | not listed | 1 | 6-7/day | 4 |
| American at Shreveport (SHV) | not listed | 1 | 6-7/day | 2 |
| American at Lynchburg (LYH) | not listed | 1 | 6-7/day | 1 |
| American at Fargo (FAR) | not listed | 1 | 6/day | 2 |
| American at Houston Hobby (HOU) | not listed | 1 | 6/day | 1 |
| American at New Bern (EWN) | not listed | 1 | 5-6/day | 1 |
| American at Abilene (ABI) | not listed | 1 | 5-6/day | 2 |
| American at Jacksonville (OAJ) | not listed | 1 | 5-6/day | 1 |
| American at Santa Barbara (SBA) | not listed | 1 | 4-5/day | 2 |
| American at Durango (DRO) | not listed | 1 | 4-5/day | 2 |
| American at Green Bay (GRB) | Concourse A | 1 | 4/day | 2 |
| American at Tokyo Haneda (HND) | Terminal 3 | 1 | 4/day | 3 |
| American at Burbank (BUR) | not listed | 1 | 3-4/day | 3 |
| American at Daytona Beach (DAB) | not listed | 1 | 3-4/day | 1 |
| American at Idaho Falls (IDA) | Concourse B | 1 | 3-4/day | 2 |
| American at Brownsville (BRO) | not listed | 1 | 3-4/day | 1 |
| American at San Luis Obispo (SBP) | not listed | 1 | 3-4/day | 2 |
| American at Alexandria (AEX) | not listed | 1 | 3/day | 1 |
| American at Billings (BIL) | Concourse B | 1 | 3/day | 2 |
| American at Bismarck (BIS) | not listed | 1 | 3/day | 2 |
| American at Monroe (MLU) | not listed | 1 | 3/day | 1 |
| American at Kahului (OGG) | not listed | 1 | 3/day | 3 |
| American at Melbourne (MLB) | not listed | 1 | 2-3/day | 1 |
| American at Bozeman (BZN) | Concourse B | 1 | 2-3/day | 3 |
| American at Kona (KOA) | not listed | 1 | 2/day | 2 |
| American at Missoula (MSO) | Concourse B | 1 | 2/day | 2 |
| American at Eugene (EUG) | Concourse A | 1 | 1-2/day | 1 |
| American at Redmond/Bend (RDM) | not listed | 1 | 1-2/day | 1 |
| American at Kalispell (FCA) | not listed | 1 | 1-2/day | 2 |
| American at Mexico City (MEX) | Terminal 1 | shared | 12/day | 7 |
| American at Fukuoka (FUK) | Terminal 2 | shared | 9/day | 3 |
| American at Lafayette (LFT) | not listed | shared | 5-6/day | 2 |
| American at Athens (ATH) | Terminal 1, Concourse C | shared | 3/day | 3 |
| American at Milan Malpensa (MXP) | Terminal 1 | shared | 3/day | 3 |
| American at Osaka Kansai (KIX) | Terminal 1 | shared | 2-3/day | 0 |
| American at Lihue (LIH) | not listed | shared | 2-3/day | 2 |
| American at Medford (MFR) | not listed | shared | 1-2/day | 1 |
| American at Pasco (PSC) | not listed | shared | 1-2/day | 1 |
| American at Zurich (ZRH) | Concourse E | shared | 1-2/day | 5 |
| American at Amsterdam (AMS) | Terminal 3, Concourse G | shared | 1-2/day | 3 |
| American at Montrose (MTJ) | not listed | shared | 1/day | 1 |
| American at Seoul Incheon (ICN) | Terminal 1 | shared | 1/day | 1 |
| American at Tokyo Narita (NRT) | Terminal 2 | shared | 1/day | 1 |